Solid phase peptide synthesis (SPPS) is an established method for peptide synthesis. It is a process in which a peptide anchored to an insoluble polymer (resin) is assembled by the successive addition of protected amino acids forming its sequence. It is a widely utilized for synthesizing peptides efficiently and reliably – from lab to commercial scale. 

At Buchiglas, we understand the critical role that reactor technology plays in achieving successful synthesis results. With decades of experience and a market leading position in peptide synthesis, we provide tailored solutions to run both manual and fully automated processes.

Our systems range from standardized to customized solutions and are available in scales from lab trough pilot/kilo lab up to commercial production volumes (5 – 500 liters). All ensuring exceptional consistency and reproducibility of synthesis results. All systems are cGMP compliant and are suitable for the production of high-quality peptide active pharmaceutical ingredients (APIs).

Key features include:     

• Compliance and safety: Our reactors are designed in accordance with cGMP standards and are ATEX-certified, ensuring safe operations.
• Durable design: designed with highly corrosion resistant materials, our reactors withstand the rigorous demands of repetitive SPPS cycles, including frequent exposure to various solvents and reagents.
• Optimized reactor design: Featuring a lowerable cylindrical glass vessel with a heating jacket, our reactors facilitate precise temperature control during critical synthesis steps.
• Efficient mixing: Equipped with a multistage mechanical stirrer, the system ensures thorough mixing of resin, solvents and reagents. Ensuring uniform reaction conditions essential for effective coupling and deprotection.
• Convenient filtration: The swing out filter plate design allows for efficient filter cloth replacement and easy cleaning. The valuable product remains in the reactor as the resin bound peptides are retained while solvents pass through.
• Enhanced heating options: An optional heatable bottom plate provides additional temperature transfer, for optimizing of reaction conditions during the various process.
• Customization: We offer both standardized configurations as well as fully customized solutions to meet specific process and operational requirements, accommodating various scales and complexities.
   

Find out more about our standardized portfolio of peptide synthesizers (from 10l to 50l).

Automation features include:
 

• Gravimetric or volumetric dosing with automated pumps: Integrated load cells (gravimetric) or flowmeters (volumetric), paired with high precision automated pumps, ensure accurate and reproducible delivery of solvents and reagents throughout all reaction steps stages. Alternatively, various types of dosing pumps can be used. These combinations guarantee optimal flow control, which are essential for high quality peptide synthesis and process reliability.
• Real time reaction monitoring: Advanced control systems allow continuous monitoring of reaction parameters (e.g., volume, weight, time, temperature, pH), supporting in process control and facilitating immediate adjustments for maximum efficiency and yield.
• Time controlled synthesis steps: Precise programming of deprotection and coupling durations ensures optimal reaction conditions, helping to prevent incomplete reactions or unwanted side reactions ensuring high peptide purity.
   

With Buchiglas peptide synthesizers, whether manually operated or fully automated, researchers, kilo lab operators and production chemists can confidently achieve high quality, reproducible peptide synthesis, tailored precisely to your unique processes and production needs.

Since decades, globally leading peptide manufacturers use Buchiglas peptide synthesizers in various scales for the successful development and cGMP production of highest quality peptide products.

For customized peptide synthesizer solutions, please get in touch with us directly or via our local distributor.