Production scale reactor systems

BE type 1000 liter glass lined reactor with glass overhead BE type 1000 liter glass lined reactor with glass overhead

Customized process reactor systems for demanding pharmaceutical and chemical applications up to 10’000 liters
 

Buchiglas specializes in engineering and building of complete reaction systems for production scales ranging from 250 to 10’000 liters. 

Glass-lined steel reactor:250 - 10'000 liter
Pressure: -1.0 (FV) to +0.5 bar
Temperature: -60 °C (-90 °C) to +200 °C
Material:Borosilicate glass 3.3, glass-lined steel, PTFE, PFA, tantalum

We develop customized solutions precisely aligned with your processes and requirements.

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By combining glass lined steel (or Hastelloy®) reactors with distillation overheads made from borosilicate 3.3 using our proprietary flexible glass piping system buchiflex. We build customized, highly corrosion resistant solutions optimized for cGMP requirements and in full compliance with ATEX regulations. 

Our systems are designed to support seamless scale up, provide process visibility, ensure operational reliability and production output second to none. Our operations focused designs and highly reliable, sturdy apparatus components lead to maximized operational performance and shortest possible down times (during campaign switches and cleaning). 
 

Typical process equipment applications

Our production scale systems are designed for a wide range of chemical processes, including:

  • Active pharmaceutical ingredients (APIs)
  • Highly potent active pharmaceutical ingredients (HPAPIs) 
  • Chemical synthesis (organic & inorganic)
  • Extraction & evaporation
  • Purification & crystallization
  • Destillation & reflux destillation
  • Azeotropic distillation 
  • Cryogenic reactions (low temperature chemistry)
  • Solvent recovery, recycling & purification
  • Acid recovery, recycling & purification
  • Agrochemicals
  • Fine chemicals / Specialty chemicals 
  • Flavors & fragrances
  • Pigments & dyes
  • Detergents & tensides
  • Coatings, paints & adhesives
  • Explosives & propellants
  • Electronic chemicals
  • Semiconductor chemicals 
  • Specialty polymers
  • Battery chemicals
  • Precious Metals
  • Catalysts

Key features & advantages of production systems:

Full customization                                                    Customized process plants through the integration of diverse functionalities, including dosing pumps and weighing systems, ensuring that the systems are optimized for the specific process requirements.
Flexible pipingBuilt with our proprietary buchiflex glass piping system (DN15 – DN150) for flexible, stress-free piping connections and quick changes with short downtimes due to its flexibility.
Corrosion resistance          Combinations of glass lined steel (or Hastelloy®), borosilicate glass 3.3, fluoropolymers and ceramics guarantee highest levels of corrosion resistance.
Process visibility

Glass overheads allow visual monitoring of the process, even at production scale – visibility is assurance.

 

Examples for production scale reactor systems

Technical data – process systems:

Volume>250 -10’000 liters (DIN AE / BE type )
Pressure                                   -1.0 (FV) to +0.5 bar in glass distillation overhead  (higher reactor pressures possible by using split-off valves)
Temperature-60 °C to +200 °C
MaterialsBorosilicate glass 3.3, glass-lined steel, PTFE, PFA, Hastelloy® (C22/ C276), tantalum, titanium, silicon carbide (SiC)

Why choose Buchiglas for production scale process systems?

We offer more than just equipment; we provide complete, engineered solutions all from one source – on site, on time and performing. From reactor vessel, customized glass overhead to auxiliary equipment, our systems are fully integrated to maximize operational performance, efficiency, safety and service life. Buchiglas acts as a one stop shop from basic design, engineering, manufacturing/procurement to assembly and installation on site (including FAT, SAT, commissioning and IQ/OQ).

 

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Do you have any questions? Would you like to get in touch with us personally? Ask our specialists.  We look forward to hearing from you!