chemReactor GR - glass reactor system

Glass pilot reactor and pilot plant - Multipurpose reaction and distillation plant for start-ups

Glass reactor: 15, 30, 60 liter
Pressure: -1.0 (FV) to +0.5 bar
Temperature: -60 °C (-90 °C) to +200 °C
Material: Borosilicate glass 3.3, glass-lined steel, PTFE, PFA, tantalum

A clean-room setup and other materials are available to meet your specific process requirements. 

Performance and reliability are key issues in the explosion proof design of Buchi glass reaction systems. The inert materials allow safe processing in an inert atmosphere of a wide range of solvents and acids in a completely sealed glass reaction system under full vacuum. Multiple chemical reaction steps are performed safely in the same setup.

The system consists of:

  • Reactor, solid jacketed full view glass reactor to easily improve and control chemical reactions by visual observation
  • Distillation glass overhead built with buchiflex components (unique flexible ball - socket joints) for mulitple, reliable processes under full vacuum

The BR/GR type chemReactor is a basic pilot reactor system for chemical process development, scale-up, process simulation and kilo-scale cGMP production in batch and semi-batch operation.

We produce complete solutions for chemical processing: Reactor systems including accessories like sampling devices, pH probes, rectification columns with structured packing, process monitoring and control as well as integration of auxiliary equipment such as temperature control units, nutsche filters / dryers, gas scrubbers or mixing vessels.

Standard package

  • Jacketed full glass reactor
  • Multipurpose glass distillation overhead
  • Stainless steel frame, supporting flexible glass superstructure
  • ATEX Zone 1 (0), CE, cGMP
  • CIP capable
  • FDA conform, highly corrosion resistant
  • Complete documentation

Standard options

  • chemReactor BR type distillation glass overhead
  • Reactor lift for easy opening and cleaning
  • Triple wall reactor vessel
  • Sampling device
  • pH monitoring and control
  • Gas introduction (Nitrogen purging and active gas)
  • Vacuum / exhaust piping
  • Additional feeders / receivers
  • Solid feeding
  • IQ, OQ, PQ

Glass dome / Glass lined cover plate

  • Glass cover dome (15, 30, 60 liter)
  • Glass-lined steel cover (60 liter)
  • Fast-action closure for addition of solids
  • 8 connection nozzles

Distillation glass overhead

Buchi chemReactors GR 15 - 60  (15, 30, 60 liter) are available in the compact K-Design. Buchi chemReactors GR 60 is also available with vertical condensers.

  • Unique flexible ball-socket joints
  • Feed vessel for liquid addition
  • Distillation column / vapor duct with pressure gauge and bursting disc
  • Spiral condenser with vacuum / exhaust connection
  • Vertical condensers or horizontal setup (compact design)
  • Receiver vessel for collection of distillate
  • Dean stark phase separator
  • Vacuum / pressure equalization and distribution piping
  • Self-draining «buchiflex» glass piping

Typical applications

  • Chemical synthesis  
  • Extraction / evaporation  
  • Purification / crystallization  
  • Separation  
  • API manufacturing  
  • Peptide production 


  • Process development 
  • Scale-up 
  • Cryogenic reactions 
  • Small scale production 
  • Pilot plant / kilo lab